{"id":1643,"date":"2024-12-30T16:55:53","date_gmt":"2024-12-30T16:55:53","guid":{"rendered":"https:\/\/journal.nncf.kz\/?p=1643"},"modified":"2025-02-04T10:58:58","modified_gmt":"2025-02-04T10:58:58","slug":"metabolic-dysfunction-associated-fatty-liver-disease-in-the-elderly-people","status":"publish","type":"post","link":"https:\/\/journal.nncf.kz\/kz\/metabolic-dysfunction-associated-fatty-liver-disease-in-the-elderly-people\/","title":{"rendered":"METABOLIC DYSFUNCTION-ASSOCIATED FATTY LIVER DISEASE IN THE ELDERLY PEOPLE"},"content":{"rendered":"

Received: 11.10.2024 Accepted: 15.11.2024 Published online: 30.12.2024
\nDOI: 10.26212\/2227-1937.2025.54.51.003<\/a>
\n\u0423\u0414\u041a: 616.36-003.826-053.9
\nMETABOLIC DYSFUNCTION-ASSOCIATED FATTY LIVER DISEASE IN THE ELDERLY PEOPLE
\nV.S. Rakhmetova1, ORCID: https:\/\/orcid.org\/0000-0001-5721-6409
\nS.M. Sarkulova1, ORCID: https:\/\/orcid.org\/0009-0002-1033-1685
\nD.A.Urazalina2, ORCID: https:\/\/orcid.org\/0009-0009-0439-1786
\nN.K. Azhibayeva1, ORCID: https:\/\/orcid.org\/0009-0001-1322-0171
\nA.K. Zhangereyeva1, ORCID: https:\/\/orcid.org\/0009-0006-7288-4986
\n1\u00abAstana Medical University\u00bb, Astana, Kazakhstan
\n2\u00abCentral Clinical Hospital of veterans of the Patriotic War\u00bb Astana, Kazakhstan
\nResume
\nBackground. As the global population ages, metabolic disorders are becoming increasingly prevalent, leading to a significant
\nrise in fatty liver disease among the elderly. Metabolic-associated fatty liver disease, formerly known as non-alcoholic fatty
\nliver disease, is now the most common liver disease. Closely linked to metabolic disorders like obesity, type 2 diabetes, and
\ndyslipidemia, Metabolic-associated fatty liver disease currently affects 24% of the adult population, equating to one billion
\nindividuals worldwide.
\nPurpose of study. To analyze the incidence structure of metabolically associated fatty liver disease in the elderly population
\nand to determine the mechanisms of liver aging that affect the prevalence and mortality from this disease in an elderly cohort
\nof individuals.
\nMaterial and methods of study. For this literature review, we analyzed 32 scientific publications, including reviews, original
\narticles, and meta-analyses, published between 2012 and 2024. We conducted a literature search using databases such as
\nGoogle Scholar, Web of Science, PubMed, Scopus, and Abridged Index Medicus.
\nResults. Reviewing the available literature sources has revealed the prevalence of fatty liver disease peaking at the age of 40\u2013
\n50 in men and 60\u201369 in women but decreasing in the older cohorts (>75 years). The mechanisms of liver cell aging influence
\nthe course of this disease in old patients have been identified as well. However, there are no data indicated concerning the
\ndirect impact on prevalence and association with fibrosis in the elderly population.
\nConclusion. Conflicting data on the prevalence of metabolic-associated fatty liver disease among the diagnosed elderly
\npatients highlight the need for further research to realise the mechanisms underlying the age-related changes in the liver. The
\nstudy of this disease in elderly persons is rather important to improve the quality of life and optimising medical care and
\ndeveloping prevention and treatment strategies.
\nKeywords: Non-alcoholic Fatty Liver Disease, Metabolic Dysfunction-Associated Steatotic Liver Disease, Fatty Liver Disease,
\nOld Age, Aging, Prevalence<\/p>\n

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