{"id":1199,"date":"2023-12-28T14:38:25","date_gmt":"2023-12-28T14:38:25","guid":{"rendered":"https:\/\/journal.nncf.kz\/?p=1199"},"modified":"2024-04-18T12:34:04","modified_gmt":"2024-04-18T12:34:04","slug":"%d0%bf%d0%be%d0%bd%d0%b8%d0%bc%d0%b0%d0%bd%d0%b8%d0%b5-%d0%ba%d0%be%d0%bd%d1%86%d0%b5%d0%bf%d1%86%d0%b8%d0%b8-%d0%bf%d0%b5%d1%80%d0%b5%d0%bf%d1%80%d0%be%d0%b3%d1%80%d0%b0%d0%bc%d0%bc%d0%b8%d1%80%d0%be","status":"publish","type":"post","link":"https:\/\/journal.nncf.kz\/kz\/%d0%bf%d0%be%d0%bd%d0%b8%d0%bc%d0%b0%d0%bd%d0%b8%d0%b5-%d0%ba%d0%be%d0%bd%d1%86%d0%b5%d0%bf%d1%86%d0%b8%d0%b8-%d0%bf%d0%b5%d1%80%d0%b5%d0%bf%d1%80%d0%be%d0%b3%d1%80%d0%b0%d0%bc%d0%bc%d0%b8%d1%80%d0%be\/","title":{"rendered":"\u041f\u041e\u041d\u0418\u041c\u0410\u041d\u0418\u0415 \u041a\u041e\u041d\u0426\u0415\u041f\u0426\u0418\u0418 \u041f\u0415\u0420\u0415\u041f\u0420\u041e\u0413\u0420\u0410\u041c\u041c\u0418\u0420\u041e\u0412\u0410\u041d\u0418\u042f \u0412\u041e\u0417\u0420\u0410\u0421\u0422\u0410"},"content":{"rendered":"

\u041f\u043e\u043b\u0443\u0447\u0435\u043d\u0430: 22 \u0441\u0435\u043d\u0442\u044f\u0431\u0440\u044f 2023\/ \u041f\u0440\u0438\u043d\u044f\u0442\u0430: 16 \u043d\u043e\u044f\u0431\u0440\u044f\/ \u041e\u043f\u0443\u0431\u043b\u0438\u043a\u043e\u0432\u0430\u043d\u0430 online: 28 \u0434\u0435\u043a\u0430\u0431\u0440\u044f 2023
\n\u0423\u0414\u041a: 577.24
\nDOI: \/10.26212\/2227-1937.2023.55.94.017<\/a><\/p>\n

\u0410.\u0421. \u0416\u0430\u043a\u0443\u043f\u043e\u0432\u04301, ORCID: http:\/\/orcid:0000-0003-4950-160X
\n\u0410.\u0410. \u0422\u0443\u0440\u043c\u0443\u0445\u0430\u043c\u0431\u0435\u0442\u043e\u0432\u04302, ORCID: http:\/\/orcid:0000-0002-4668-3295
\n\u0422.\u041c. \u0421\u0430\u043b\u0438\u0435\u04323, ORCID: http:\/\/orcid:0000-0001-5696-6363
\n\u041f.\u0411. \u0421\u0438\u043d\u0433\u04451, ORCID: http:\/\/orcid:0000-0002-9571-0974
\n1 \u0428\u043a\u043e\u043b\u0430 \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u044b \u041d\u0430\u0437\u0430\u0440\u0431\u0430\u0435\u0432 \u0423\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442, \u0433. \u0410\u0441\u0442\u0430\u043d\u0430
\n2 \u041d\u0410\u041e \u00ab\u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u041a\u0430\u0440\u0430\u0433\u0430\u043d\u0434\u044b\u00bb, \u0433. \u041a\u0430\u0440\u0430\u0433\u0430\u043d\u0434\u044b
\n3 \u041d\u0430\u0443\u0447\u043d\u043e-\u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u0441\u043a\u0438\u0439 \u0438\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u0444\u0443\u043d\u0434\u0430\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u043e\u0439 \u0438 \u043f\u0440\u0438\u043a\u043b\u0430\u0434\u043d\u043e\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u044b \u0438\u043c\u0435\u043d\u0438 \u0411. \u0410\u0442\u0447\u0430\u0431\u0430\u0440\u043e\u0432\u0430 (\u041d\u0418\u0418\u0424\u041f\u041c), \u0433.\u0410\u043b\u043c\u0430\u0442\u044b<\/p>\n

\u041f\u041e\u041d\u0418\u041c\u0410\u041d\u0418\u0415 \u041a\u041e\u041d\u0426\u0415\u041f\u0426\u0418\u0418 \u041f\u0415\u0420\u0415\u041f\u0420\u041e\u0413\u0420\u0410\u041c\u041c\u0418\u0420\u041e\u0412\u0410\u041d\u0418\u042f \u0412\u041e\u0417\u0420\u0410\u0421\u0422\u0410<\/p>\n

\u0420\u0435\u0437\u044e\u043c\u0435: \u041f\u0435\u0440\u0435\u043f\u0440\u043e\u0433\u0440\u0430\u043c\u043c\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430 \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u044f\u0435\u0442 \u0441\u043e\u0431\u043e\u0439 \u043d\u043e\u0432\u044b\u0439 \u043c\u0435\u0442\u043e\u0434 \u0441\u043e\u0437\u0434\u0430\u043d\u0438\u044f \u043f\u0430\u0446\u0438\u0435\u043d\u0442-\u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u044b\u0445 \u0442\u043a\u0430\u043d\u0435\u0439
\n\u0434\u043b\u044f \u0442\u0440\u0430\u043d\u0441\u043f\u043b\u0430\u043d\u0442\u0430\u0446\u0438\u0438. \u0414\u0430\u043d\u043d\u044b\u0439 \u043c\u0435\u0442\u043e\u0434 \u043f\u043e\u0437\u0432\u043e\u043b\u044f\u0435\u0442 \u043e\u0431\u043e\u0439\u0442\u0438 \u0446\u0438\u043a\u043b \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u043e\u0439 \u0434\u0438\u0444\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0440\u043e\u0432\u043a\u0438, \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u043d\u044b\u0439 \u0434\u043b\u044f
\n\u0438\u043d\u0434\u0443\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u043f\u043b\u044e\u0440\u0438\u043f\u043e\u0442\u0435\u043d\u0442\u043d\u044b\u0445 \u0441\u0442\u0432\u043e\u043b\u043e\u0432\u044b\u0445 \u043a\u043b\u0435\u0442\u043e\u043a (iPS) \u0438 \u044f\u0434\u0435\u0440\u043d\u043e-\u0442\u0440\u0430\u043d\u0441\u0444\u0435\u0440\u043d\u044b\u0445 \u044d\u043c\u0431\u0440\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0445 \u0441\u0442\u0432\u043e\u043b\u043e\u0432\u044b\u0445
\n\u043a\u043b\u0435\u0442\u043e\u043a (NT-ES). \u0414\u0430\u043d\u043d\u044b\u0435 \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0432\u044b\u0437\u044b\u0432\u0430\u044e\u0442 \u0431\u043e\u043b\u044c\u0448\u043e\u0439 \u0438\u043d\u0442\u0435\u0440\u0435\u0441 \u0432 \u0440\u0435\u0433\u0435\u043d\u0435\u0440\u0430\u0442\u0438\u0432\u043d\u043e\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0435. \u041d\u0435\u0441\u043c\u043e\u0442\u0440\u044f \u043d\u0430
\n\u043e\u0447\u0435\u0432\u0438\u0434\u043d\u044b\u0439 \u043f\u043e\u0442\u0435\u043d\u0446\u0438\u0430\u043b \u043a\u043b\u0435\u0442\u043e\u0447\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 iPS \u0438 NT-ES, \u0441\u0443\u0449\u0435\u0441\u0442\u0432\u0443\u0435\u0442 \u043d\u0435\u0441\u043a\u043e\u043b\u044c\u043a\u043e \u043f\u0440\u043e\u0431\u043b\u0435\u043c, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e
\n\u043f\u0440\u0435\u043e\u0434\u043e\u043b\u0435\u0442\u044c, \u043f\u0440\u0435\u0436\u0434\u0435 \u0447\u0435\u043c \u0434\u0430\u043d\u043d\u044b\u0435 \u043c\u0435\u0442\u043e\u0434\u044b \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0441\u0442\u0430\u043d\u0443\u0442 \u0431\u0435\u0437\u043e\u043f\u0430\u0441\u043d\u044b\u043c\u0438 \u0438 \u0440\u0443\u0442\u0438\u043d\u043d\u044b\u043c\u0438. \u0410\u043b\u044c\u0442\u0435\u0440\u043d\u0430\u0442\u0438\u0432\u043e\u0439
\n\u0432\u044b\u0448\u0435\u043f\u0435\u0440\u0435\u0447\u0438\u0441\u043b\u0435\u043d\u043d\u044b\u043c \u043c\u0435\u0442\u043e\u0434\u0430\u043c \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043f\u0435\u0440\u0435\u043f\u0440\u043e\u0433\u0440\u0430\u043c\u043c\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430, \u043a\u043e\u0442\u043e\u0440\u043e\u0435 \u043d\u0430\u043f\u0440\u0430\u0432\u043b\u0435\u043d\u043e \u043d\u0430 \u043e\u043c\u043e\u043b\u043e\u0436\u0435\u043d\u0438\u0435
\n\u0441\u043f\u0435\u0446\u0438\u0430\u043b\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u0444\u0443\u043d\u043a\u0446\u0438\u0439 \u0441\u0442\u0430\u0440\u043e\u0439 \u043a\u043b\u0435\u0442\u043a\u0438 \u0431\u0435\u0437 \u043f\u0440\u043e\u0445\u043e\u0436\u0434\u0435\u043d\u0438\u044f \u0434\u0435-\u0434\u0438\u0444\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0440\u043e\u0432\u043a\u0438. \u0422\u0430\u043a\u0436\u0435 \u0432 \u043e\u0442\u043b\u0438\u0447\u0438\u0435 \u043e\u0442 \u043a\u043b\u0435\u0442\u043e\u0447\u043d\u043e\u0439
\n\u0442\u0435\u0440\u0430\u043f\u0438\u0438 iPS \u0438 NT-ES, \u043f\u0435\u0440\u0435\u043f\u0440\u043e\u0433\u0440\u0430\u043c\u043c\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430 \u043d\u0435 \u0442\u0440\u0435\u0431\u0443\u0435\u0442 \u043f\u0440\u043e\u0445\u043e\u0436\u0434\u0435\u043d\u0438\u044f \u043f\u0435\u0440\u0435\u043f\u0440\u043e\u0433\u0440\u0430\u043c\u043c\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f
\n\u0447\u0435\u0440\u0435\u0437 \u044d\u043c\u0431\u0440\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u0443\u044e \u0441\u0442\u0430\u0434\u0438\u044e. \u0420\u0430\u0431\u043e\u0442\u044b \u043f\u043e \u043f\u0435\u0440\u0435\u043f\u0440\u043e\u0433\u0440\u0430\u043c\u043c\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044e \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430 \u0431\u044b\u043b\u0438 \u0432 \u043e\u0441\u043d\u043e\u0432\u043d\u043e\u043c \u0441\u043e\u0441\u0440\u0435\u0434\u043e\u0442\u043e\u0447\u0435\u043d\u044b \u043d\u0430
\n\u043e\u0434\u043d\u043e\u043c \u0430\u0441\u043f\u0435\u043a\u0442\u0435 \u2013 \u044d\u043f\u0438\u0433\u0435\u043d\u043e\u043c\u0435. \u042d\u043f\u0438\u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u043e\u043c\u043e\u043b\u043e\u0436\u0435\u043d\u0438\u0435 \u0431\u044b\u043b\u043e \u0434\u043e\u0441\u0442\u0438\u0433\u043d\u0443\u0442\u043e in vitro \u0432 \u043e\u0442\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0438 \u0434\u0435\u0434\u0438\u0444\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0440\u043e\u0432\u043a\u0438 \u0441 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u0435\u043c \u0444\u0430\u043a\u0442\u043e\u0440\u043e\u0432 \u043f\u0435\u0440\u0435\u043f\u0440\u043e\u0433\u0440\u0430\u043c\u043c\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f iPS \u043a\u043b\u0435\u0442\u043e\u043a. \u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u0434\u0438\u043d\u0430\u043c\u0438\u043a\u0438
\n\u043f\u0435\u0440\u0435\u043f\u0440\u043e\u0433\u0440\u0430\u043c\u043c\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f \u044d\u043f\u0438\u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430 (eAge) \u043f\u043e\u043a\u0430\u0437\u0430\u043b\u0438, \u0447\u0442\u043e \u043e\u0442\u043b\u0438\u0447\u0438\u0435 eAge \u043e\u0442 \u043f\u0435\u0440\u0435\u043f\u0440\u043e\u0433\u0440\u0430\u043c\u043c\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f
\n\u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u043c\u043e\u0436\u0435\u0442 \u0431\u044b\u0442\u044c \u0432 \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u0441\u0442\u0435\u043f\u0435\u043d\u0438 \u043e\u0431\u044a\u044f\u0441\u043d\u0435\u043d\u043e \u0438\u0445 \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u043e\u0439 \u043a\u0438\u043d\u0435\u0442\u0438\u043a\u043e\u0439. \u041f\u0435\u0440\u0435\u043f\u0440\u043e\u0433\u0440\u0430\u043c\u043c\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435
\n\u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430 \u0442\u0430\u043a\u0436\u0435 \u0431\u044b\u043b\u043e \u0434\u043e\u0441\u0442\u0438\u0433\u043d\u0443\u0442\u043e in vivo \u0438 \u0431\u044b\u043b\u043e \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u043e, \u0447\u0442\u043e \u043e\u043d\u043e \u0443\u0432\u0435\u043b\u0438\u0447\u0438\u0432\u0430\u0435\u0442 \u043f\u0440\u043e\u0434\u043e\u043b\u0436\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u0436\u0438\u0437\u043d\u0438 \u0443 \u043c\u044b\u0448\u0435\u0439 \u0441
\n\u043f\u0440\u0435\u0436\u0434\u0435\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u043c \u0441\u0442\u0430\u0440\u0435\u043d\u0438\u0435\u043c. \u0412 \u0434\u0430\u043d\u043d\u043e\u0439 \u0441\u0442\u0430\u0442\u044c\u0435 \u043f\u0440\u0438\u0432\u043e\u0434\u044f\u0442\u0441\u044f \u0434\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u0430 \u0442\u043e\u0433\u043e, \u0447\u0442\u043e \u043f\u0435\u0440\u0435\u043f\u0440\u043e\u0433\u0440\u0430\u043c\u043c\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435
\n\u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u043c\u043e\u0436\u043d\u043e \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u043e\u0432\u0430\u0442\u044c in vitro \u0438 in vivo, \u0430 \u0442\u0430\u043a\u0436\u0435 \u043d\u0430\u043f\u0440\u0430\u0432\u043b\u0435\u043d\u0438\u044f \u0431\u0443\u0434\u0443\u0449\u0438\u0445 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439 \u0434\u043b\u044f \u0443\u0433\u043b\u0443\u0431\u043b\u0435\u043d\u0438\u044f \u043d\u0430\u0448\u0435\u0433\u043e
\n\u043f\u043e\u043d\u0438\u043c\u0430\u043d\u0438\u044f \u0434\u0430\u043d\u043d\u043e\u0433\u043e \u044f\u0432\u043b\u0435\u043d\u0438\u044f, \u043a\u043e\u0442\u043e\u0440\u043e\u0435 \u0434\u0430\u0441\u0442 \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0435 \u043f\u0440\u0435\u0438\u043c\u0443\u0449\u0435\u0441\u0442\u0432\u0430 \u0432 \u0440\u0435\u0433\u0435\u043d\u0435\u0440\u0430\u0442\u0438\u0432\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438.
\n\u041a\u043b\u044e\u0447\u0435\u0432\u044b\u0435 \u0441\u043b\u043e\u0432\u0430: \u043f\u0435\u0440\u0435\u043f\u0440\u043e\u0433\u0440\u0430\u043c\u043c\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430, \u044d\u043f\u0438\u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u043e\u043c\u043e\u043b\u043e\u0436\u0435\u043d\u0438\u0435, \u043f\u0435\u0440\u0435\u043d\u043e\u0441 \u044f\u0434\u0435\u0440 \u0441\u043e\u043c\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445
\n\u043a\u043b\u0435\u0442\u043e\u043a (SCNT), iPS \u043a\u043b\u0435\u0442\u043a\u0438, \u0444\u0430\u043a\u0442\u043e\u0440\u044b \u043f\u0435\u0440\u0435\u043f\u0440\u043e\u0433\u0440\u0430\u043c\u043c\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f, \u044d\u043f\u0438\u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0447\u0430\u0441\u044b, eAge.<\/p>\n

\u0421\u041f\u0418\u0421\u041e\u041a \u041b\u0418\u0422\u0415\u0420\u0410\u0422\u0423\u0420\u042b
\n1 Briggs, R., and King, T.J. (1952). Transplantation of
\nliving nuclei from blastula cells into enucleated frogs\u2019
\neggs. Proc. Natl. Acad. Sci. U.S.A. 38, 455\u2013463.
\n10.1073\/pnas.38.5.455.
\n2 Gurdon, J.B. (1962). Adult frogs derived from the nuclei
\nof single somatic cells. Developmental Biology 4, 256\u2013273.
\n10.1016\/0012-1606(62)90043-X.
\n3 Wilmut, I., Schnieke, A.E., McWhir, J., Kind, A.J., and
\nCampbell, K.H.S. (1997). Viable offspring derived from
\nfetal and adult mammalian cells. Nature 385, 810\u2013813.
\n10.1038\/385810a0.
\n4 Mizutani, E., Ono, T., Li, C., Maki-Suetsugu, R., and
\nWakayama, T. (2008). Propagation of senescent mice
\nusing nuclear transfer embryonic stem cell lines. genesis
\n46, 478\u2013483. 10.1002\/dvg.20420.
\n5 Wakayama, S., Mizutani, E., and Wakayama, T. (2010).
\nProduction of Cloned Mice from Somatic Cells, ES Cells,
\nand Frozen Bodies. In Methods in Enzymology (Elsevier),
\npp. 151\u2013169. 10.1016\/S0076-6879(10)76009-2.
\n6 Dimos, J.T., Rodolfa, K.T., Niakan, K.K., Weisenthal, L.M.,
\nMitsumoto, H., Chung, W., Croft, G.F., Saphier, G., Leibel, R.,
\nGoland, R., et al. (2008). Induced Pluripotent Stem Cells
\nGenerated from Patients with ALS Can Be Differentiated
\ninto Motor Neurons. Science 321, 1218\u20131221.
\n10.1126\/science.1158799.
\n7 Takahashi, K., and Yamanaka, S. (2006). Induction of
\nPluripotent Stem Cells from Mouse Embryonic and Adult
\nFibroblast Cultures by Defined Factors. Cell 126, 663\u2013676.
\n10.1016\/j.cell.2006.07.024.
\n8 Lapasset, L., Milhavet, O., Prieur, A., Besnard, E., Babled,
\nA., A\u00eft-Hamou, N., Leschik, J., Pellestor, F., Ramirez, J.-M.,
\nDe Vos, J., et al. (2011). Rejuvenating senescent and
\ncentenarian human cells by reprogramming through the
\npluripotent state. Genes Dev. 25, 2248\u20132253.
\n10.1101\/gad.173922.111.
\n9 L\u00f3pez-Ot\u00edn, C., Blasco, M.A., Partridge, L., Serrano, M.,
\nand Kroemer, G. (2013). The Hallmarks of Aging. Cell 153,
\n1194\u20131217. 10.1016\/j.cell.2013.05.039.
\n10 L\u00f3pez-Ot\u00edn, C., Blasco, M.A., Partridge, L., Serrano, M.,
\nand Kroemer, G. (2023). Hallmarks of aging: An
\nexpanding universe. Cell 186, 243\u2013278.
\n10.1016\/j.cell.2022.11.001.
\n11 Marion, R.M., Strati, K., Li, H., Tejera, A., Schoeftner, S.,
\nOrtega, S., Serrano, M., and Blasco, M.A. (2009). Telomeres
\nAcquire Embryonic Stem Cell Characteristics in Induced
\nPluripotent Stem Cells. Cell Stem Cell 4, 141\u2013154.
\n10.1016\/j.stem.2008.12.010.
\n12 Schaetzlein, S., Lucas-Hahn, A., Lemme, E., Kues, W.A.,
\nDorsch, M., Manns, M.P., Niemann, H., and Rudolph, K.L.
\n(2004). Telomere length is reset during early mammalian
\n130
\nembryogenesis. Proc. Natl. Acad. Sci. U.S.A. 101, 8034\u2013
\n8038. 10.1073\/pnas.0402400101.
\n13 Liu, L., Bailey, S.M., Okuka, M., Mu\u00f1oz, P., Li, C., Zhou, L.,
\nWu, C., Czerwiec, E., Sandler, L., Seyfang, A., et al. (2007).
\nTelomere lengthening early in development. Nat Cell Biol
\n9, 1436\u20131441. 10.1038\/ncb1664.
\n14 Mari\u00f3n, R.M., Strati, K., Li, H., Murga, M., Blanco, R.,
\nOrtega, S., Fernandez-Capetillo, O., Serrano, M., and
\nBlasco, M.A. (2009). A p53-mediated DNA damage
\nresponse limits reprogramming to ensure iPS cell
\ngenomic integrity. Nature 460, 1149\u20131153.
\n10.1038\/nature08287.
\n15 Suhr, S.T., Chang, E.A., Tjong, J., Alcasid, N., Perkins,
\nG.A., Goissis, M.D., Ellisman, M.H., Perez, G.I., and Cibelli,
\nJ.B. (2010). Mitochondrial Rejuvenation After Induced
\nPluripotency. PLoS ONE 5, e14095.
\n10.1371\/journal.pone.0014095.
\n16 Herberts, C.A., Kwa, M.S., and Hermsen, H.P. (2011).
\nRisk factors in the development of stem cell therapy. J
\nTransl Med 9, 29. 10.1186\/1479-5876-9-29.
\n17 Abad, M., Mosteiro, L., Pantoja, C., Ca\u00f1amero, M.,
\nRayon, T., Ors, I., Gra\u00f1a, O., Meg\u00edas, D., Dom\u00ednguez, O.,
\nMart\u00ednez, D., et al. (2013). Reprogramming in vivo
\nproduces teratomas and iPS cells with totipotency
\nfeatures. Nature 502, 340\u2013345. 10.1038\/nature12586.
\n18 Ohnishi, K., Semi, K., Yamamoto, T., Shimizu, M.,
\nTanaka, A., Mitsunaga, K., Okita, K., Osafune, K., Arioka, Y.,
\nMaeda, T., et al. (2014). Premature Termination of
\nReprogramming In Vivo Leads to Cancer Development
\nthrough Altered Epigenetic Regulation. Cell 156, 663\u2013677.
\n10.1016\/j.cell.2014.01.005.
\n19 Manukyan, M., and Singh, P.B. (2012). Epigenetic
\nrejuvenation. Genes to Cells 17, 337\u2013343. 10.1111\/j.1365-
\n2443.2012.01595.x.
\n20 Singh, P.B., and Zacouto, F. (2010). Nuclear
\nreprogramming and epigenetic rejuvenation. J Biosci 35,
\n315\u2013319. 10.1007\/s12038-010-0034-2.
\n21 Singh, P.B., and Zhakupova, A. (2022). Age
\nreprogramming: cell rejuvenation by partial
\nreprogramming. Development 149, dev200755.
\n10.1242\/dev.200755.
\n22 Manukyan, M., and Singh, P.B. (2014). Epigenome
\nrejuvenation: HP1\u03b2 mobility as a measure of pluripotent
\nand senescent chromatin ground states. Sci Rep 4, 4789.
\n10.1038\/srep04789.
\n23 Horvath, S. (2013). DNA methylation age of human
\ntissues and cell types. Genome Biology 14, R115.
\n10.1186\/gb-2013-14-10-r115.
\n24 Armstrong, N.J., Mather, K.A., Thalamuthu, A., Wright,
\nM.J., Trollor, J.N., Ames, D., Brodaty, H., Schofield, P.R.,
\nSachdev, P.S., and Kwok, J.B. (2017). Aging, exceptional
\nlongevity and comparisons of the Hannum and Horvath
\nepigenetic clocks. Epigenomics 9, 689\u2013700. 10.2217\/epi2016-0179.
\n25 Vanyushin, B.F., Nemirovsky, L.E., Klimenko, V.V.,
\nVasiliev, V.K., and Belozersky, A.N. (1973). The 5-
\nmethylcytosine in DNA of rats. Tissue and age specificity
\nand the changes induced by hydrocortisone and other
\nagents. Gerontologia 19, 138\u2013152.
\n26 Jung, M., and Pfeifer, G.P. (2015). Aging and DNA
\nmethylation. BMC Biol 13, 7. 10.1186\/s12915-015-0118-
\n4.
\n27 Bell, C.G., Lowe, R., Adams, P.D., Baccarelli, A.A., Beck,
\nS., Bell, J.T., Christensen, B.C., Gladyshev, V.N., Heijmans,
\nB.T., Horvath, S., et al. (2019). DNA methylation aging
\nclocks: challenges and recommendations. Genome Biol 20,
\n249. 10.1186\/s13059-019-1824-y.
\n28 Mendelsohn, A.R., and Larrick, J.W. (2019). Epigenetic
\nAge Reversal by Cell-Extrinsic and Cell-Intrinsic Means.
\nRejuvenation Research 22, 439\u2013446.
\n10.1089\/rej.2019.2271.
\n29 Bogdanovi\u0107, O., Smits, A.H., de la Calle Mustienes, E.,
\nTena, J.J., Ford, E., Williams, R., Senanayake, U., Schultz,
\nM.D., Hontelez, S., van Kruijsbergen, I., et al. (2016). Active
\nDNA demethylation at enhancers during the vertebrate
\nphylotypic period. Nat Genet 48, 417\u2013426.
\n10.1038\/ng.3522.
\n30 Field, A.E., Robertson, N.A., Wang, T., Havas, A., Ideker,
\nT., and Adams, P.D. (2018). DNA Methylation Clocks in
\nAging: Categories, Causes, and Consequences. Molecular
\nCell 71, 882\u2013895. 10.1016\/j.molcel.2018.08.008.
\n31 Unnikrishnan, A., Freeman, W.M., Jackson, J., Wren, J.D.,
\nPorter, H., and Richardson, A. (2019). The role of DNA
\nmethylation in epigenetics of aging. Pharmacology &
\nTherapeutics 195, 172\u2013185.
\n10.1016\/j.pharmthera.2018.11.001.
\n32 Hannum, G., Guinney, J., Zhao, L., Zhang, L., Hughes, G.,
\nSadda, S., Klotzle, B., Bibikova, M., Fan, J.-B., Gao, Y., et al.
\n(2013). Genome-wide Methylation Profiles Reveal
\nQuantitative Views of Human Aging Rates. Molecular Cell
\n49, 359\u2013367. 10.1016\/j.molcel.2012.10.016.
\n33 Lu, A.T., Fei, Z., Haghani, A., Robeck, T.R., Zoller, J.A., Li,
\nC.Z., Lowe, R., Yan, Q., Zhang, J., Vu, H., et al. (2023).
\nUniversal DNA methylation age across mammalian
\ntissues. Nat Aging. 10.1038\/s43587-023-00462-6.
\n34 Horvath, S., and Raj, K. (2018). DNA methylation-based
\nbiomarkers and the epigenetic clock theory of ageing. Nat
\nRev Genet 19, 371\u2013384. 10.1038\/s41576-018-0004-3.
\n35 Gibbs, W.W. (2014). Biomarkers and ageing: The clockwatcher. Nature 508, 168\u2013170. 10.1038\/508168a.
\n36 Gladyshev, V.N. (2021). The Ground Zero of
\nOrganismal Life and Aging. Trends in Molecular Medicine
\n27, 11\u201319. 10.1016\/j.molmed.2020.08.012.
\n37 Olova, N., Simpson, D.J., Marioni, R.E., and Chandra, T.
\n(2019). Partial reprogramming induces a steady decline
\nin epigenetic age before loss of somatic identity. Aging
\nCell 18, e12877. 10.1111\/acel.12877.
\n38 Ohnuki, M., Tanabe, K., Sutou, K., Teramoto, I.,
\nSawamura, Y., Narita, M., Nakamura, M., Tokunaga, Y.,
\nNakamura, M., Watanabe, A., et al. (2014). Dynamic
\nregulation of human endogenous retroviruses mediates
\nfactor-induced reprogramming and differentiation
\npotential. Proc. Natl. Acad. Sci. U.S.A. 111, 12426\u201312431.
\n10.1073\/pnas.1413299111.
\n39 Ocampo, A., Reddy, P., Martinez-Redondo, P., PlateroLuengo, A., Hatanaka, F., Hishida, T., Li, M., Lam, D., Kurita,
\nM., Beyret, E., et al. (2016). In Vivo Amelioration of AgeAssociated Hallmarks by Partial Reprogramming. Cell
\n167, 1719-1733.e12. 10.1016\/j.cell.2016.11.052.
\n40 Scaffidi, P., and Misteli, T. (2005). Reversal of the
\ncellular phenotype in the premature aging disease
\nHutchinson-Gilford progeria syndrome. Nat Med 11, 440\u2013
\n445. 10.1038\/nm1204.
\n41 Simpson, D.J., Olova, N.N., and Chandra, T. (2021).
\nCellular reprogramming and epigenetic rejuvenation. Clin
\nEpigenet 13, 170. 10.1186\/s13148-021-01158-7.
\n42 Parras, A., V\u00edlchez-Acosta, A., Desd\u00edn-Mic\u00f3, G., Mrabti,
\nC., Rechsteiner, C., Battiston, F., Branchina, C., P\u00e9rez, K.,
\nSempoux, C., and Ocampo, A. (2022). In vivo
\nreprogramming leads to premature death due to hepatic
\nand intestinal failure. bioRxiv, 2022.05.27.493700.
\n10.1101\/2022.05.27.493700.
\n43 Hong, H., Takahashi, K., Ichisaka, T., Aoi, T., Kanagawa,
\nO., Nakagawa, M., Okita, K., and Yamanaka, S. (2009).
\nSuppression of induced pluripotent stem cell generation
\n131
\nby the p53\u2013p21 pathway. Nature 460, 1132\u20131135.
\n10.1038\/nature08235.
\n44 Singh, P.B., and Newman, A.G. (2018). Age
\nreprogramming and epigenetic rejuvenation. Epigenetics
\n& Chromatin 11, 73. 10.1186\/s13072-018-0244-7.
\n45 Brown, J.P., Wei, W., and Sedivy, J.M. (1997). Bypass of
\nSenescence After Disruption of p21 CIP1\/WAF1 Gene in
\nNormal Diploid Human Fibroblasts. Science 277, 831\u2013
\n834. 10.1126\/science.277.5327.831.
\n46 Gill, D., Parry, A., Santos, F., Okkenhaug, H., Todd, C.D.,
\nHernando-Herraez, I., Stubbs, T.M., Milagre, I., and Reik,
\nW. (2022). Multi-omic rejuvenation of human cells by
\nmaturation phase transient reprogramming. eLife 11,
\ne71624. 10.7554\/eLife.71624.
\n47 Efe, J.A., Hilcove, S., Kim, J., Zhou, H., Ouyang, K., Wang,
\nG., Chen, J., and Ding, S. (2011). Conversion of mouse
\nfibroblasts into cardiomyocytes using a direct
\nreprogramming strategy. Nat Cell Biol 13, 215\u2013222.
\n10.1038\/ncb2164.
\n48 Nagy, A., and Nagy, K. (2010). The mysteries of induced
\npluripotency: where will they lead? Nat Methods 7, 22\u201324.
\n10.1038\/nmeth.f.292.
\n49 Guo, L., Karoubi, G., Duchesneau, P., Shutova, M.V.,
\nSung, H.-K., Tonge, P., Bear, C., Rogers, I., Nagy, A., and
\nWaddell, T.K. (2017). Generation of Induced Progenitorlike Cells from Mature Epithelial Cells Using Interrupted
\nReprogramming. Stem Cell Reports 9, 1780\u20131795.
\n10.1016\/j.stemcr.2017.10.022.
\n50 Gurdon, J.B., and Melton, D.A. (2008). Nuclear
\nReprogramming in Cells. Science 322, 1811\u20131815.
\n10.1126\/science.1160810.
\n51 Yamanaka, S., and Blau, H.M. (2010). Nuclear
\nreprogramming to a pluripotent state by three
\napproaches. Nature 465, 704\u2013712. 10.1038\/nature09229.
\n52 Sarkar, T.J., Quarta, M., Mukherjee, S., Colville, A., Paine,
\nP., Doan, L., Tran, C.M., Chu, C.R., Horvath, S., Qi, L.S., et al.
\n(2020). Transient non-integrative expression of nuclear
\nreprogramming factors promotes multifaceted
\namelioration of aging in human cells. Nat Commun 11,
\n1545. 10.1038\/s41467-020-15174-3.
\n53 Lu, Y., Brommer, B., Tian, X., Krishnan, A., Meer, M.,
\nWang, C., Vera, D.L., Zeng, Q., Yu, D., Bonkowski, M.S., et al.
\n(2020). Reprogramming to recover youthful epigenetic
\ninformation and restore vision. Nature 588, 124\u2013129.
\n10.1038\/s41586-020-2975-4.
\n54 Rodr\u00edguez-Matell\u00e1n, A., Alcazar, N., Hern\u00e1ndez, F.,
\nSerrano, M., and \u00c1vila, J. (2020). In Vivo Reprogramming
\nAmeliorates Aging Features in Dentate Gyrus Cells and
\nImproves Memory in Mice. Stem Cell Reports 15, 1056\u2013
\n1066. 10.1016\/j.stemcr.2020.09.010.
\n55 Shahini, A., Rajabian, N., Choudhury, D., Shahini, S.,
\nVydiam, K., Nguyen, T., Kulczyk, J., Santarelli, T., Ikhapoh,
\nI., Zhang, Y., et al. (2021). Ameliorating the hallmarks of
\ncellular senescence in skeletal muscle myogenic
\nprogenitors in vitro and in vivo. Sci. Adv. 7, eabe5671.
\n10.1126\/sciadv.abe5671.
\n56 Browder, K.C., Reddy, P., Yamamoto, M., Haghani, A.,
\nGuillen, I.G., Sahu, S., Wang, C., Luque, Y., Prieto, J., Shi, L.,
\net al. (2022). In vivo partial reprogramming alters ageassociated molecular changes during physiological aging
\nin mice. Nat Aging 2, 243\u2013253. 10.1038\/s43587-022-
\n00183-2.
\n57 Chondronasiou, D., Gill, D., Mosteiro, L., Urdinguio, R.G.,
\nBerenguer\u2011Llergo, A., Aguilera, M., Durand, S.,
\nAprahamian, F., Nirmalathasan, N., Abad, M., et al. (2022).
\nMulti\u2011omic rejuvenation of naturally aged tissues by a
\nsingle cycle of transient reprogramming. Aging Cell 21.
\n10.1111\/acel.13578.
\n58 Roux, A.E., Zhang, C., Paw, J., Zavala-Solorio, J.,
\nMalahias, E., Vijay, T., Kolumam, G., Kenyon, C., and
\nKimmel, J.C. (2022). Diverse partial reprogramming
\nstrategies restore youthful gene expression and
\ntransiently suppress cell identity. Cell Systems 13, 574-
\n587.e11. 10.1016\/j.cels.2022.05.002.
\n59 Cheng, F., Wang, C., Ji, Y., Yang, B., Shu, J., Shi, K., Wang,
\nL., Wang, S., Zhang, Y., Huang, X., et al. (2022). Partial
\nreprogramming strategy for intervertebral disc
\nrejuvenation by activating energy switch. Aging Cell 21.
\n10.1111\/acel.13577.
\n60 Alle, Q., Le Borgne, E., Bensadoun, P., Lemey, C., B\u00e9chir,
\nN., Gabanou, M., Estermann, F., Bertrand\u2011Gaday, C.,
\nPessemesse, L., Toupet, K., et al. (2022). A single short
\nreprogramming early in life initiates and propagates an
\nepigenetically related mechanism improving fitness and
\npromoting an increased healthy lifespan. Aging Cell 21,
\ne13714. 10.1111\/acel.13714.
\n61 Yang, J.-H., Hayano, M., Griffin, P.T., Amorim, J.A.,
\nBonkowski, M.S., Apostolides, J.K., Salfati, E.L., Blanchette,
\nM., Munding, E.M., Bhakta, M., et al. (2023). Loss of
\nepigenetic information as a cause of mammalian aging.
\nCell 186, 305-326.e27. 10.1016\/j.cell.2022.12.027.
\n62 Tang, Y., Liu, M.-L., Zang, T., and Zhang, C.-L. (2017).
\nDirect Reprogramming Rather than iPSC-Based
\nReprogramming Maintains Aging Hallmarks in Human
\nMotor Neurons. Front. Mol. Neurosci. 10, 359.
\n10.3389\/fnmol.2017.00359.
\n63 Maza, I., Caspi, I., Zviran, A., Chomsky, E., Rais, Y.,
\nViukov, S., Geula, S., Buenrostro, J.D., Weinberger, L.,
\nKrupalnik, V., et al. (2015). Transient acquisition of
\npluripotency during somatic cell transdifferentiation with
\niPSC reprogramming factors. Nat Biotechnol 33, 769\u2013774.
\n10.1038\/nbt.3270.
\n64 Chen, Y., L\u00fcttmann, F.F., Schoger, E., Sch\u00f6ler, H.R.,
\nZelaray\u00e1n, L.C., Kim, K.-P., Haigh, J.J., Kim, J., and Braun, T.
\n(2021). Reversible reprogramming of cardiomyocytes to a
\nfetal state drives heart regeneration in mice. Science 373,
\n1537\u20131540. 10.1126\/science.abg5159.
\n65 Hishida, T., Yamamoto, M., Hishida-Nozaki, Y., Shao, C.,
\nHuang, L., Wang, C., Shojima, K., Xue, Y., Hang, Y.,
\nShokhirev, M., et al. (2022). In vivo partial cellular
\nreprogramming enhances liver plasticity and
\nregeneration. Cell Reports 39, 110730.
\n10.1016\/j.celrep.2022.110730.
\n66 Wang, C., Rabadan Ros, R., Martinez-Redondo, P., Ma,
\nZ., Shi, L., Xue, Y., Guillen-Guillen, I., Huang, L., Hishida, T.,
\nLiao, H.-K., et al. (2021). In vivo partial reprogramming of
\nmyofibers promotes muscle regeneration by remodeling
\nthe stem cell niche. Nat Commun 12, 3094.
\n10.1038\/s41467-021-23353-z.
\n67 G\u00f6bel, C., Goetzke, R., Eggermann, T., and Wagner, W.
\n(2018). Interrupted reprogramming into induced
\npluripotent stem cells does not rejuvenate human
\nmesenchymal stromal cells. Sci Rep 8, 11676.
\n10.1038\/s41598-018-30069-6.
\n68 Hou, P., Li, Y., Zhang, X., Liu, C., Guan, J., Li, H., Zhao, T.,
\nYe, J., Yang, W., Liu, K., et al. (2013). Pluripotent Stem Cells
\nInduced from Mouse Somatic Cells by Small-Molecule
\nCompounds. Science 341, 651\u2013654.
\n10.1126\/science.1239278.
\n69 Guan, J., Wang, G., Wang, J., Zhang, Z., Fu, Y., Cheng, L.,
\nMeng, G., Lyu, Y., Zhu, J., Li, Y., et al. (2022). Chemical
\nreprogramming of human somatic cells to pluripotent
\nstem cells. Nature 605, 325\u2013331. 10.1038\/s41586-022-
\n04593-5.
\n70 Yang, J.-H., Petty, C.A., Dixon-McDougall, T., Lopez, M.V.,
\nTyshkovskiy, A., Maybury-Lewis, S., Tian, X., Ibrahim, N.,
\n132
\nChen, Z., Griffin, P.T., et al. (2023). Chemically induced
\nreprogramming to reverse cellular aging. Aging 15, 5966\u2013
\n5989. 10.18632\/aging.204896.<\/p>\n

\r\n\t\"\"\r\n\r\n\t
\r\n\t\t\u0421\u043a\u0430\u0447\u0430\u0442\u044c: \u041f\u041e\u041d\u0418\u041c\u0410\u041d\u0418\u0415 \u041a\u041e\u041d\u0426\u0415\u041f\u0426\u0418\u0418 \u041f\u0415\u0420\u0415\u041f\u0420\u041e\u0413\u0420\u0410\u041c\u041c\u0418\u0420\u041e\u0412\u0410\u041d\u0418\u042f \u0412\u041e\u0417\u0420\u0410\u0421\u0422\u0410<\/a>\r\n\t\t
<\/div>\r\n\t\t
\u0421\u043a\u0430\u0447\u0430\u043d\u043e: 176, \u0440\u0430\u0437\u043c\u0435\u0440: 1.8 MB<\/div>\r\n\t<\/div>\r\n\t\r\n<\/div>\r\n\r\n