{"id":1696,"date":"2024-12-30T17:07:42","date_gmt":"2024-12-30T17:07:42","guid":{"rendered":"https:\/\/journal.nncf.kz\/?p=1696"},"modified":"2025-02-04T10:56:10","modified_gmt":"2025-02-04T10:56:10","slug":"%d1%80ulmonary-renal-interactions-in-chronic-lung-diseases-current-state-of-the-problem","status":"publish","type":"post","link":"https:\/\/journal.nncf.kz\/en\/%d1%80ulmonary-renal-interactions-in-chronic-lung-diseases-current-state-of-the-problem\/","title":{"rendered":"\u0420ULMONARY-RENAL INTERACTIONS IN CHRONIC LUNG DISEASES – CURRENT STATE OF THE PROBLEM"},"content":{"rendered":"

Received: 17.10.2024 Accepted: 27.11.2024 Published online: 30.12.2024
\nDOI: 10.26212\/2227-1937.2025.84.83.020<\/a>
\n\u0423\u0414\u041a: 616.24-002:616.61-008
\n\u0420ULMONARY-RENAL INTERACTIONS IN CHRONIC LUNG DISEASES – CURRENT STATE OF THE PROBLEM
\nL.K. Ibrayeva 1, ORCID https:\/\/orcid.org\/0000-0002-9917-0258
\nO.S. Klassen 2, ORCID https:\/\/orcid.org\/0000-0002-9267-2968
\nA.R. Alina 1, ORCID https:\/\/orcid.org\/0000-0002-3229-1506
\nI.V. Bacheva 1, ORCID https:\/\/orcid.org\/0000-0002-5576-8637,
\nA.A. Nygimetova 3, ORCID https:\/\/orcid.org\/0009-0004-5985-6257
\n\u00b9Department of Internal Medicine, Karaganda Medical University, Karaganda, Kazakhstan
\n2Institute of Life Sciences, Karaganda Medical University, Karaganda, Kazakhstan
\n3Pulmonology Department, Regional Clinical Hospital, Karaganda, Kazakhstan
\nCorresponding author: Olga Klassen. E-mail: klassen_os@mail.ru. ORCID: 0009-0004-5985-6257
\nResume: The first quarter of the 21st century is nearly complete, and the medical community increasingly faces the
\nchallenges of global population aging and the steady rise in chronic disease prevalence. It is evident that the complete or
\npartial loss of function in one organ affects the status of others. The kidneys and lungs jointly regulate fluid homeostasis, acidbase balance, immune response, and the production of biologically active molecules. For instance, renal insufficiency leads to
\nfluid overload and hypertension, thereby exacerbating disease severity and increasing mortality in patients with chronic lung
\ndiseases, such as interstitial lung diseases and COPD. At the same time, chronic lung diseases significantly affect kidney
\nhealth, both through hypoxia and nephrotoxic effects of treatments. Rheumatic diseases, such as systemic sclerosis, should be
\nspecifically highlighted, as fibrosis develops in both organs. Understanding inter-organ interactions is crucial for preventing
\ncomplications and improving survival. These factors underscore the necessity of recognizing these interrelations when
\nselecting treatment strategies. Ideally, a multidisciplinary approach should be employed, involving specialists in
\npulmonology, nephrology, and rheumatology. Collaborative efforts will enable proper treatment, timely detection, and
\nprevention of complications. Applying knowledge of inter-organ relationships will not only improve the quality of medical
\ncare but also reduce the financial burden on the healthcare system. This review attempts to describe the mechanisms linking
\nkidney damage and pulmonary dysfunction, with a focus on chronic kidney disease (CKD) and its impact on lung health. It
\nemphasizes the importance of early detection of CKD and outlines potential biomarkers for assessing damage to both organs,
\nas well as therapeutic targets.
\nThe search was conducted in electronic databases such as Scopus, Web of Science, PubMed, and Google Scholar, using
\nrelevant keywords: “COPD and CKD,” “ILD and CKD”, “Kidney function and lung function,” “Renal dysfunction and respiratory
\nfailure.” The search span was 15 years, from 2009 to 2024, and included only open-access articles in English, encompassing
\nall types of studies, focusing solely on adults and animal studies. Pediatric studies were excluded from consideration.
\nKey words: Pulmorenal Syndrome, Chronic Lung Diseases, Pulmonary Fibrosis, Chronic Kidney Disease, Renal Dysfunction<\/p>\n","protected":false},"excerpt":{"rendered":"

Received: 17.10.2024 Accepted: 27.11.2024 Published online: 30.12.2024 DOI: 10.26212\/2227-1937.2025.84.83.020 \u0423\u0414\u041a: 616.24-002:616.61-008 \u0420ULMONARY-RENAL INTERACTIONS IN CHRONIC LUNG DISEASES – CURRENT STATE OF THE PROBLEM L.K. Ibrayeva<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[47,1],"tags":[],"_links":{"self":[{"href":"https:\/\/journal.nncf.kz\/en\/wp-json\/wp\/v2\/posts\/1696"}],"collection":[{"href":"https:\/\/journal.nncf.kz\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/journal.nncf.kz\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/journal.nncf.kz\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/journal.nncf.kz\/en\/wp-json\/wp\/v2\/comments?post=1696"}],"version-history":[{"count":2,"href":"https:\/\/journal.nncf.kz\/en\/wp-json\/wp\/v2\/posts\/1696\/revisions"}],"predecessor-version":[{"id":1817,"href":"https:\/\/journal.nncf.kz\/en\/wp-json\/wp\/v2\/posts\/1696\/revisions\/1817"}],"wp:attachment":[{"href":"https:\/\/journal.nncf.kz\/en\/wp-json\/wp\/v2\/media?parent=1696"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/journal.nncf.kz\/en\/wp-json\/wp\/v2\/categories?post=1696"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/journal.nncf.kz\/en\/wp-json\/wp\/v2\/tags?post=1696"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}