{"id":1510,"date":"2024-09-28T13:32:59","date_gmt":"2024-09-28T13:32:59","guid":{"rendered":"https:\/\/journal.nncf.kz\/?p=1510"},"modified":"2024-11-01T13:33:07","modified_gmt":"2024-11-01T13:33:07","slug":"clinical-features-of-covid-19-infection-in-newborns-a-retrospective-analysis","status":"publish","type":"post","link":"https:\/\/journal.nncf.kz\/en\/clinical-features-of-covid-19-infection-in-newborns-a-retrospective-analysis\/","title":{"rendered":"CLINICAL FEATURES OF COVID-19 INFECTION IN NEWBORNS: A RETROSPECTIVE ANALYSIS"},"content":{"rendered":"

Received: 26.06.2024 Accepted: 23.09.2024 Published online: 28.09.2024
\nDOI: 10.26212\/2227-1937.2024.55.81.008<\/a>
\nUDC: 616.24
\nYe. Mukhaliyev1, ORCID: https:\/\/orcid.org\/0000-0002-0996-1428
\nG. Kuttykuzhanova1, ORCID: https:\/\/orcid.org\/0000-0003-1876-2217
\nA. Tanirbergenova1, ORCID: https:\/\/orcid.org\/0000-0001-6002-4029
\nA. Katarbayev1, ORCID: https:\/\/orcid.org\/0000-0002-8623-7441
\nG. Akdauletova2, ORCID: https:\/\/orcid.org\/0009-0005-8388-0879
\n1Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
\n2Pediatric Infectious Diseases Hospital, Almaty, Kazakhstan
\nCLINICAL FEATURES OF COVID-19 INFECTION IN NEWBORNS: A RETROSPECTIVE ANALYSIS
\nResume:
\nBackground. The COVID-19 pandemic has significantly impacted all age groups, including newborns. During the fifth surge,
\nthe prevalence of the Omicron variant among infants increased dramatically. While SARS-CoV-2 is generally milder in
\nchildren than adults, newborns are vulnerable due to their immature immune systems. Clinical manifestations in newborns
\ncan range from asymptomatic to severe cases with respiratory distress or multi-organ dysfunction.
\nPurpose of study. Description of clinical manifestations, course and outcomes of coronavirus infection in newborns.
\nMaterials and methods of study. A retrospective analysis was conducted on 110 newborns with COVID-19 admitted to the
\nChildren’s Clinical Infectious Diseases Hospital of Almaty between 2021 and early 2022. The study used electronic medical
\nrecords as the source of research data. Demographic data such as age and sex were collected, along with epidemiological data
\nincluding international or domestic travel within two weeks prior to the onset of the disease, known exposure to a person
\nwith positive SARS-CoV-2 infection, and a history of pregnancy.
\nResults. The infants’ mean age was 17 days, with 44 boys (40%) and 66 girls (60%). Four newborns were admitted to the
\nhospital at less than seven days of life. When analyzing the severity of the cases, the following proportions of newborns were
\nobserved: (3\/110, 2.7%) were asymptomatic, (44\/110, 40%) had mild symptoms, (57\/110, 51.8%) were moderately severe,
\n(4\/110, 3.6%) severe, and (2\/110, 1.8%) had very severe illness. The majority (68.4%) were hospitalized within three days
\nof symptom onset. Fever was common, and all infants underwent chest CTs. Despite some severe cases, 99% had favorable
\noutcomes, with only one fatality.
\nConclusion. This study indicates that most COVID-19 infections in newborns were contracted from household contacts.
\nClinical symptoms in infants included fever, catarrhal symptoms, and signs of intoxication, with some showing normal
\ntemperatures. Laboratory findings varied, with common changes including monocytosis and neutrophilia. Respiratory
\ncomplications, such as bronchitis and pneumonia, were prevalent. Comorbidities, particularly congenital disorders, increased
\nthe risk of severe outcomes and mortality. Most newborns recovered within 1-2 weeks, though viral carriage persisted in
\nmany.
\nKeywords: COVID-19, Newborns, Infants, SARS-CoV-2, Retrospective Study, Pediatrics.<\/p>\n

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