{"id":1153,"date":"2023-12-28T14:12:30","date_gmt":"2023-12-28T14:12:30","guid":{"rendered":"https:\/\/journal.nncf.kz\/?p=1153"},"modified":"2024-04-18T12:36:24","modified_gmt":"2024-04-18T12:36:24","slug":"%d1%80%d0%be%d0%bb%d1%8c-%d0%b4%d0%b8%d1%81%d0%bb%d0%b8%d0%bf%d0%b8%d0%b4%d0%b5%d0%bc%d0%b8%d0%b8-%d1%83-%d0%bf%d0%b0%d1%86%d0%b8%d0%b5%d0%bd%d1%82%d0%be%d0%b2-%d0%bf%d0%be%d1%81%d0%bb%d0%b5-%d0%b0","status":"publish","type":"post","link":"https:\/\/journal.nncf.kz\/en\/%d1%80%d0%be%d0%bb%d1%8c-%d0%b4%d0%b8%d1%81%d0%bb%d0%b8%d0%bf%d0%b8%d0%b4%d0%b5%d0%bc%d0%b8%d0%b8-%d1%83-%d0%bf%d0%b0%d1%86%d0%b8%d0%b5%d0%bd%d1%82%d0%be%d0%b2-%d0%bf%d0%be%d1%81%d0%bb%d0%b5-%d0%b0\/","title":{"rendered":"\u0420\u041e\u041b\u042c \u0414\u0418\u0421\u041b\u0418\u041f\u0418\u0414\u0415\u041c\u0418\u0418 \u0423 \u041f\u0410\u0426\u0418\u0415\u041d\u0422\u041e\u0412 \u041f\u041e\u0421\u041b\u0415 \u0410\u041e\u0420\u0422\u041e-\u041a\u041e\u0420\u041e\u041d\u0410\u0420\u041d\u041e\u0413\u041e \u0428\u0423\u041d\u0422\u0418\u0420\u041e\u0412\u0410\u041d\u0418\u042f"},"content":{"rendered":"

\u041f\u043e\u043b\u0443\u0447\u0435\u043d\u0430: 9 \u043d\u043e\u044f\u0431\u044f 2023\/ \u041f\u0440\u0438\u043d\u044f\u0442\u0430: 24 \u043d\u043e\u044f\u0431\u0440\u044f 2023\/ \u041e\u043f\u0443\u0431\u043b\u0438\u043a\u043e\u0432\u0430\u043d\u0430 online: 28 \u0434\u0435\u043a\u0430\u0431\u0440\u044f 2023
\n\u0423\u0414\u041a 616-089-07
\nDOI: 10.26212\/2227-1937.2023.75.44.003<\/a><\/p>\n

\u0410. \u0413. \u0420\u0430\u043a\u0438\u0448\u0435\u0432\u04301 ORCID: https:\/\/orcid.org\/0000-0001-9842-962X
\n\u0414. \u0422. \u0421\u0435\u043d\u043a\u0438\u0431\u0430\u0435\u0432\u04302 ORCID: https:\/\/orcid.org\/0009-0009-6245-8336
\n\u0421. \u0411. \u0415\u0440\u0434\u0435\u0441\u043e\u04324, 5 ORCID: https:\/\/orcid.org\/0000-0002-6377-7744
\n\u041c. \u0428. \u0410\u0431\u0434\u0438\u043b\u044c\u0434\u0430\u0435\u04322 ORCID: https:\/\/orcid.org\/0000-0003-2436-9454
\n\u041c. \u0410. \u041d\u0443\u0440\u0436\u0430\u043d\u043e\u0432\u04302, 3, ORCID: https:\/\/orcid.org\/0000-0003-2561-8707
\n1 \u0413\u043e\u0440\u043e\u0434\u0441\u043a\u0430\u044f \u0431\u043e\u043b\u044c\u043d\u0438\u0446\u0430 \u0433. \u041a\u043e\u043d\u0430\u0435\u0432, \u041a\u0430\u0437\u0430\u0445\u0441\u0442\u0430\u043d
\n2 \u041d\u0430\u0443\u0447\u043d\u043e-\u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u0441\u043a\u0438\u0439 \u0418\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u041a\u0430\u0440\u0434\u0438\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u0412\u043d\u0443\u0442\u0440\u0435\u043d\u043d\u0438\u0445 \u0411\u043e\u043b\u0435\u0437\u043d\u0435\u0439
\n3\u041a\u0430\u0437\u0430\u0445\u0441\u0442\u0430\u043d\u0441\u043a\u0438\u0439 \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0423\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 “\u0412\u044b\u0441\u0448\u0430\u044f \u0448\u043a\u043e\u043b\u0430 \u043e\u0431\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f”, \u0433.\u0410\u043b\u043c\u0430\u0442\u044b, \u041a\u0430\u0437\u0430\u0445\u0441\u0442\u0430\u043d
\n4 \u0428\u043a\u043e\u043b\u0430 \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u044b, \u041d\u0430\u0437\u0430\u0440\u0431\u0430\u0435\u0432 \u0423\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442, \u0410\u0441\u0442\u0430\u043d\u0430, \u041a\u0430\u0437\u0430\u0445\u0441\u0442\u0430\u043d
\n5 \u0420\u0413\u041f \u043d\u0430 \u041f\u0425\u0412 \u00ab\u041d\u0430\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0439 \u0446\u0435\u043d\u0442\u0440 \u043e\u0431\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f\u00bb \u041c\u0417 \u0420\u041a, \u0410\u0441\u0442\u0430\u043d\u0430, \u041a\u0430\u0437\u0430\u0445\u0441\u0442\u0430\u043d<\/p>\n

\u0420\u041e\u041b\u042c \u0414\u0418\u0421\u041b\u0418\u041f\u0418\u0414\u0415\u041c\u0418\u0418 \u0423 \u041f\u0410\u0426\u0418\u0415\u041d\u0422\u041e\u0412 \u041f\u041e\u0421\u041b\u0415 \u0410\u041e\u0420\u0422\u041e-\u041a\u041e\u0420\u041e\u041d\u0410\u0420\u041d\u041e\u0413\u041e \u0428\u0423\u041d\u0422\u0418\u0420\u041e\u0412\u0410\u041d\u0418\u042f<\/p>\n

\u0420\u0435\u0437\u044e\u043c\u0435: \u0414\u0438\u0441\u043b\u0438\u043f\u0438\u0434\u0435\u043c\u0438\u0438 \u2013 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f \u0432 \u0441\u0438\u0441\u0442\u0435\u043c\u0435 \u0442\u0440\u0430\u043d\u0441\u043f\u043e\u0440\u0442\u0430 \u043b\u0438\u043f\u0438\u0434\u043e\u0432 \u0438 \u043b\u0438\u043f\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u043e\u0432, \u043f\u0440\u043e\u044f\u0432\u043b\u044f\u044e\u0449\u0435\u0435\u0441\u044f
\n\u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u044b\u043c\u0438 \u043f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044f\u043c\u0438 \u0445\u043e\u043b\u0435\u0441\u0442\u0435\u0440\u0438\u043d\u0430 (\u0425\u0421), \u0442\u0440\u0438\u0433\u043b\u0438\u0446\u0435\u0440\u0438\u0434\u043e\u0432 (\u0422\u0413), \u043b\u0438\u043f\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430 \u043d\u0438\u0437\u043a\u043e\u0439 \u043f\u043b\u043e\u0442\u043d\u043e\u0441\u0442\u0438 (\u041b\u041f\u041d\u041f) \u0438
\n\u043e\u0431\u0440\u0430\u0442\u043d\u044b\u043c \u0441\u043d\u0438\u0436\u0435\u043d\u0438\u0435\u043c \u0443\u0440\u043e\u0432\u043d\u0435\u0439 \u043b\u0438\u043f\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u043e\u0432 \u0432\u044b\u0441\u043e\u043a\u043e\u0439 \u043f\u043b\u043e\u0442\u043d\u043e\u0441\u0442\u0438 (\u041b\u041f\u0412\u041f), \u043a\u043e\u0442\u043e\u0440\u043e\u0435 \u043d\u0430\u0438\u0431\u043e\u043b\u0435\u0435 \u0447\u0430\u0441\u0442\u043e \u0430\u0441\u0441\u043e\u0446\u0438\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u0441
\n\u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u044b\u043c \u0440\u0438\u0441\u043a\u043e\u043c \u0430\u0442\u0435\u0440\u043e\u0441\u043a\u043b\u0435\u0440\u043e\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 (\u0410\u0421\u0421\u0417). \u041c\u0438\u0440\u043e\u0432\u044b\u0435 \u0434\u0430\u043d\u043d\u044b\u0435 2019 \u0433\u043e\u0434\u0430
\n\u043f\u043e \u0441\u043c\u0435\u0440\u0442\u043d\u043e\u0441\u0442\u0438 \u0432\u0441\u043b\u0435\u0434\u0441\u0442\u0432\u0438\u0435 \u0438\u0448\u0435\u043c\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u0441\u0435\u0440\u0434\u0446\u0430 \u043f\u043e\u043a\u0430\u0437\u044b\u0432\u0430\u044e\u0442, \u0447\u0442\u043e \u0438\u0437 8.54 \u043c\u0438\u043b\u043b\u0438\u043e\u043d\u043e\u0432 \u0441\u043c\u0435\u0440\u0442\u0435\u0439, \u043e\u043a\u043e\u043b\u043e
\n\u043f\u043e\u043b\u043e\u0432\u0438\u043d\u044b \u0441\u0432\u044f\u0437\u0430\u043d\u043e \u0441 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u044b\u043c \u0443\u0440\u043e\u0432\u043d\u0435\u043c \u041b\u041f\u041d\u041f.
\n\u0412 \u043d\u0430\u0441\u0442\u043e\u044f\u0449\u0435\u0435 \u0432\u0440\u0435\u043c\u044f \u0434\u0438\u0441\u043b\u0438\u043f\u0438\u0434\u0435\u043c\u0438\u0438 \u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0439 \u0438 \u0440\u0430\u0441\u0448\u0438\u0440\u044f\u044e\u0449\u0435\u0439\u0441\u044f \u043e\u0431\u043b\u0430\u0441\u0442\u044c\u044e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439, \u0432\u043a\u043b\u044e\u0447\u0430\u044f
\n\u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u043e\u0442\u043d\u043e\u0441\u0438\u0442\u0435\u043b\u044c\u043d\u043e \u0438\u0445 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u043e\u0439 \u043e\u0441\u043d\u043e\u0432\u044b \u0438 \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043f\u0440\u043e\u0438\u0441\u0445\u043e\u0436\u0434\u0435\u043d\u0438\u0438.
\n\u041e\u0434\u043d\u0430\u043a\u043e \u0434\u0438\u0441\u043b\u0438\u043f\u0438\u0434\u0435\u043c\u0438\u0438 \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u043f\u043e\u0441\u043b\u0435 \u0440\u0435\u0432\u0430\u0441\u043a\u0443\u043b\u044f\u0440\u0438\u0437\u0430\u0446\u0438\u0438 \u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0430 \u0438\u043c\u0435\u044e\u0442 \u0441\u0432\u043e\u0438 \u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e\u0441\u0442\u0438 \u0432
\n\u043f\u0440\u0435\u0434\u043e\u043f\u0435\u0440\u0430\u0446\u0438\u043e\u043d\u043d\u043e\u043c \u0438 \u043f\u043e\u0441\u043b\u0435\u043e\u043f\u0435\u0440\u0430\u0446\u0438\u043e\u043d\u043d\u043e\u043c \u043f\u0435\u0440\u0438\u043e\u0434\u0435. \u041a\u043e\u043d\u0442\u0440\u043e\u043b\u044c \u0437\u0430 \u0443\u0440\u043e\u0432\u043d\u0435\u043c \u0425\u0421 \u041b\u041f\u041d\u041f \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0434\u043e \u0410\u041a\u0428, \u0432\u043a\u043b\u044e\u0447\u0430\u0435\u0442 \u0432
\n\u0441\u0435\u0431\u044f \u043f\u0440\u0438\u0435\u043c \u0432\u044b\u0441\u043e\u043a\u0438\u0445 \u0434\u043e\u0437 \u0441\u0442\u0430\u0442\u0438\u043d\u043e\u0432 \u0434\u043e \u043f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u0438\u044f \u043e\u043f\u0435\u0440\u0430\u0446\u0438\u0438, \u0442\u0430\u043a \u043a\u0430\u043a \u044d\u0442\u043e \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u044c\u043d\u043e \u0441\u043d\u0438\u0436\u0430\u0435\u0442 \u0440\u0438\u0441\u043a \u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e
\n\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u044b\u0445 \u0441\u043e\u0431\u044b\u0442\u0438\u0439 (\u043d\u0430 44%) \u0432 \u0432\u0438\u0434\u0435 \u0441\u043c\u0435\u0440\u0442\u0438 \u0438 \u0438\u043d\u0444\u0430\u0440\u043a\u0442\u0430 \u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0430. \u041f\u043e\u0441\u043b\u0435 \u0410\u041a\u0428 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0425\u0421 \u041b\u041f\u041d\u041f \u0438\u043c\u0435\u0435\u0442 \u043f\u0440\u044f\u043c\u0443\u044e
\n\u0437\u0430\u0432\u0438\u0441\u0438\u043c\u043e\u0441\u0442\u044c \u0441 \u0440\u0438\u0441\u043a\u0430\u043c\u0438 \u0441\u0435\u0440\u044c\u0435\u0437\u043d\u044b\u0445 \u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u044b\u0445 \u0441\u043e\u0431\u044b\u0442\u0438\u0439 (MACE).
\n\u0414\u0430\u043d\u043d\u044b\u0439 \u043e\u0431\u0437\u043e\u0440 \u043d\u0430 \u043e\u0441\u043d\u043e\u0432\u0435 \u0430\u043a\u0442\u0443\u0430\u043b\u044c\u043d\u044b\u0445 \u043b\u0438\u0442\u0435\u0440\u0430\u0442\u0443\u0440\u043d\u044b\u0445 \u0434\u0430\u043d\u043d\u044b\u0445 \u043f\u043e\u0437\u0432\u043e\u043b\u0438\u0442 \u0441\u0443\u043c\u043c\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u0443\u0436\u0435 \u0438\u043c\u0435\u044e\u0449\u0438\u0435\u0441\u044f \u0434\u0430\u043d\u043d\u044b\u0435 \u0438
\n\u043e\u0441\u0432\u0435\u0442\u0438\u0442\u044c \u0443\u0441\u043e\u0432\u0435\u0440\u0448\u0435\u043d\u0441\u0442\u0432\u043e\u0432\u0430\u043d\u0438\u044f, \u0432\u043a\u043b\u044e\u0447\u0430\u044f \u043a\u043b\u0430\u0441\u0441\u0438\u0444\u0438\u043a\u0430\u0446\u0438\u044e \u0434\u0438\u0441\u043b\u0438\u043f\u0438\u0434\u0435\u043c\u0438\u0439 \u0438 \u0438\u0445 \u0440\u043e\u043b\u044c \u0432 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0438 \u0430\u0442\u0435\u0440\u043e\u0441\u043a\u043b\u0435\u0440\u043e\u0437\u0430
\n\u043a\u043e\u0440\u043e\u043d\u0430\u0440\u043d\u044b\u0445 \u0430\u0440\u0442\u0435\u0440\u0438\u0439 (\u041a\u0410), \u0430 \u0442\u0430\u043a\u0436\u0435 \u043c\u0435\u0442\u043e\u0434\u044b \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0430\u0442\u0435\u0440\u043e\u0441\u043a\u043b\u0435\u0440\u043e\u0437\u0430 \u041a\u0410, \u0445\u0438\u0440\u0443\u0440\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0438 \u043c\u0435\u0434\u0438\u043a\u0430\u043c\u0435\u043d\u0442\u043e\u0437\u043d\u044b\u0435, \u0432\u043a\u043b\u044e\u0447\u0430\u044f
\n\u043d\u043e\u0432\u0435\u0439\u0448\u0438\u0435 \u043c\u0435\u0442\u043e\u0434\u044b \u043b\u0435\u0447\u0435\u043d\u0438\u044f.
\n\u041a\u043b\u044e\u0447\u0435\u0432\u044b\u0435 \u0441\u043b\u043e\u0432\u0430: \u0434\u0438\u0441\u043b\u0438\u043f\u0438\u0434\u0435\u043c\u0438\u044f, \u0430\u0442\u0435\u0440\u043e\u0441\u043a\u043b\u0435\u0440\u043e\u0437 \u043a\u043e\u0440\u043e\u043d\u0430\u0440\u043d\u044b\u0445 \u0430\u0440\u0442\u0435\u0440\u0438\u0439, \u0433\u0438\u043f\u043e\u043b\u0438\u043f\u0438\u0434\u0435\u043c\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u044f,
\n\u0430\u043e\u0440\u0442\u043e\u043a\u043e\u0440\u043e\u043d\u0430\u0440\u043d\u043e\u0435 \u0448\u0443\u043d\u0442\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435, \u0438\u043d\u0433\u0438\u0431\u0438\u0442\u043e\u0440\u044b PCSK9.<\/p>\n

\u0421\u041f\u0418\u0421\u041e\u041a \u041b\u0418\u0422\u0415\u0420\u0410\u0422\u0423\u0420\u042b
\n1 \u0410\u0440\u043e\u043d\u043e\u0432\u202f\u0414.\u202f\u041c.,\u202f\u0411\u0443\u0431\u043d\u043e\u0432\u0430\u202f\u041c.\u202f\u0413.,\u202f\u0414\u0440\u0430\u043f\u043a\u0438\u043d\u0430\u202f\u041e.\u202f\u041c.
\n\u041f\u0430\u0442\u043e\u0433\u0435\u043d\u0435\u0437 \u0430\u0442\u0435\u0440\u043e\u0441\u043a\u043b\u0435\u0440\u043e\u0437\u0430 \u0447\u0435\u0440\u0435\u0437 \u043f\u0440\u0438\u0437\u043c\u0443 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f
\n\u0444\u0443\u043d\u043a\u0446\u0438\u0439 \u043c\u0438\u043a\u0440\u043e\u0441\u043e\u0441\u0443\u0434\u043e\u0432. \/\/ \u041a\u0430\u0440\u0434\u0438\u043e\u0432\u0430\u0441\u043a\u0443\u043b\u044f\u0440\u043d\u0430\u044f
\n\u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0438 \u043f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u043a\u0430. -2021. -20(7) \u2013 \u0441. 133-142
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\n5 \u0417\u0430\u0439\u043f\u0441 \u0414.\u041f., \u041b\u0438\u0431\u0431\u0438 \u041f., \u0411\u043e\u043d\u043e\u0443 \u0420.\u041e., \u041c\u0430\u043d\u043d \u0414.\u041b., \u0413\u043e\u0440\u0434\u043e\u043d
\n\u0422.\u0424. \u0411\u043e\u043b\u0435\u0437\u043d\u0438 \u0441\u0435\u0440\u0434\u0446\u0430 \u043f\u043e \u0411\u0440\u0430\u0443\u043d\u0432\u0430\u043b\u044c\u0434\u0443. \u0412 3 \u0442. \u0422. 2. – 2023
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